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0368.4007 Structural Bioinformatics
Spring Semester 1999/2000
Graduate Course, Computer Science Department
Table of Contents:
Phone : (03) 640 6476
Office Hours: by appointment, 115 Schreiber bldg.
Time and Place:
in: room 105, Physics (Shenkar) Building
In the course we shall discuss geometric algorithms which assist in
the solution of major problems in Protein Structure analysis. We shall
concentrate on algorithmic research for protein structural comparison,
receptor-ligand docking and, if time permits, protein folding.
Since proteins are 3-dimensional geometric objects, efficient algorithms
which handle such objects can be of great benefit for the solution of these
'real-life' problems. In this sense there is much in common to the problems
occurring in protein analysis and drug design with central problems in
Computer Vision or Computational Geometry. The course will highlight these
ideas and concentrate on algorithms which originated in Computer Vision/Computational
Geometry research. Special emphasis will be given to the practical solution
of the problems at hand.
We shall shortly introduce some basic knowledge on 3-D protein structure
(for Computer Science students) and present state-of-the-art geometric
algorithms which tackle the above mentioned problems. Many of the algorithms,
which will be presented at the course, were developed at Tel Aviv University
by the Computational Structural Biology group under the supervision of
Prof. Ruth Nussinov from the Molecular Medicine Institute and Prof. Haim
Wolfson from the Computer Science Department.
SOME TOPICS THAT WILL BE DISCUSSED :
3-D Protein matching
3-D (molecular) Surface Representation
Extraction of Geometrical and Biological (3-D Motion) invariant indices.
Receptor-Ligand Docking (resembles a solution of 3-D puzzle)
Matching and Docking of Flexible 3-D structures.
The course is targeted for M.Sc. and 3rd
year B.Sc students of Computer Science. Students of other departments (e.g.
Chemistry, Biology, Medicine) may participate if they have enough
and computational maturity. No knowledge of Molecular Biology
Formal Prerequisites: Can be found on the "Idion".
Students who don't have the formal prerequisites and want to register should
approach Prof. Haim Wolfson via e-mail firstname.lastname@example.org
or via telephone: 640-6476
Recommended Web Sites:
Back to Table of contents
rcsb Internet Courses on the Principles of Protein Structure.
Institute Genome and Bioinformatics Home Page.
Comments and suggestions are welcomed at email@example.com