NON-REDUNDANT DATASET:

In order to be able to carry out a statistical analysis on the dataset, a non-redundant dataset was generated from the clusters obtained. To eliminate redundancy, the sequences of the chains comprising the interfaces in each cluster were compared, using a threshold identity of 50%. If two interface members in the same cluster share a sequence identity of more than 50% in both their chains, one member was removed from the cluster. Finally, a representative was selected for each cluster (bold). The representative is the interface that is most similar to the rest of the cluster members. 59 clusters have at least five members:

Cluster Number:	84
1opo	AC
1iru	EL
1acm	AB
1h8e	HI
1np3	BC
1g13	AB
2tbv	AC
1pju	AD
Cluster Number:	87
1ldk	DE
1eci	AB
1igq	AC
1q5y	AB
1pug	AB
1bjp	AB
Cluster Number:	88
2pro	AB
1lfd	AB
1c1y	AB
1g4k	AB
1sce	AB
1ggl	AB
1h0b	AB
1f0k	AB
1i7z	AC
1uad	AC
1igf	LJ
1mbm	AD
1aei	AB
1d0q	AB
1iz6	BC
1kkl	AH
1o7d	DE
1tcm	AB
Cluster Number:	89
1o8u	AE
1a4r	AB
1nap	AC
1f2l	AD
1nba	AD
1aip	AD
1cf7	AB
Cluster Number:	90
1c0e	AB
1mk7	AD
1ay7	AB
1h5q	AC
1jdf	AB
1fl9	AC
Cluster Number:	99
1l0o	AB
1l3b	AD
1b99	AD
1e7p	AD
1gtt	BC
1iun	AB
Cluster Number:	100
1mlc	BE
1bql	HY
1ngk	FJ
1rcm	AB
1fak	HT
1hf2	AC
1nfd	BE
1iis	AC
1jm4	AB
1br8	LI
1m2z	AD
2rdv	AC
1pg7	HX
1q6w	AE
1mhp	AH
1k8g	AB
Cluster Number:	101
1nkp	DE
1a0a	AB
1hlo	AB
1nlw	DE
1mdy	AB
1am9	AB
Cluster Number:	139
1toc	BF
1iaz	AB
1fvr	AB
1ho1	AC
1ch4	CD
Cluster Number:	140
1udv	AB
1jdp	AB
1n3j	AB
1ohz	AB
1nf2	AB
1e2t	AD
1bv4	AB
1b25	AD
1qfj	AB
1j4s	AB
1a4x	AB
1ipw	AB
1gef	AE
Cluster Number:	142
1ugw	EF
1grw	BC
1f02	IT
1reg	XY
1nln	AB
1otf	AC
1jj2	JT
1jot	AB
1ibx	AB
1m93	AC
1jjo	AE
Cluster Number:	143
1jke	AC
2rmc	AC
1hdh	AB
2mta	AC
1rtp	23
1m2n	AB
1vlz	AB
1c2y	BQ
Cluster Number:	156
1sae	AB
1d5w	BC
1nlx	AB
1ihw	AB
1pet	AD
1ir2	BG
1hv2	AB
1je8	AB
1ng7	AB
1q0w	AB
1otr	AB
1pmx	AB
1h59	AB
1jyo	EF
1pmp	AB
Cluster Number:	161
1kgz	AB
1f9a	AF
1tmk	AB
1acm	BD
1byf	AB
1q77	AB
1hlq	AB
1o17	AD
1azy	AB
Cluster Number:	162
1cdt	AB
1no1	AB
1ne2	AB
1bos	AB
1kba	AB
1l1n	AB
1dyn	AB
1nw2	GH
1fe0	AB
1dwl	AB
1kfl	AC
1bkz	AB
1ilr	12
1d0i	AB
1lm5	AB
1hjv	AD
1m9u	AB
1o77	AB
1ezf	AB
1ca0	AB
1d1z	BD
Cluster Number:	164
1bi2	AB
1hi9	AB
1d0i	AD
1nkv	AB
1c0w	AB
Cluster Number:	166
3ng1	AB
2jel	HP
1f6s	EF
1bqh	AG
1ypt	AB
1jtc	AB
1uf3	AF
1nbq	AB
1fo1	AB
1htz	AD
1f5o	AB
1mzu	BC
1hgd	AC
1dux	CF
1kg0	BC
1qc7	AB
1nco	AB
1dxx	AD
1oft	BC
1fq9	AD
1dps	AK
1i9r	AH
4pro	AB
1auv	AB
1a8v	AB
1bzw	CD
1cq1	AB
1ex2	AB
1b12	AC
1djg	AB
1upp	AC
1ob1	BC
Cluster Number:	168
1gxs	BC
1e2y	AJ
1gg4	AB
1bqo	AB
1oi4	AB
1bzq	AL
1xo1	AB
1gxs	AD
1dw0	BC
1dps	AE
Cluster Number:	174
1fo6	AD
1i7m	AC
1p27	AC
2ans	AB
1f6b	AB
Cluster Number:	175
1csk	AD
1kv0	AB
1rtp	12
1nrv	AB
1bog	BC
3cro	LR
1k4c	AC
1gcq	AC
1pq3	BF
1k9a	BE
1azz	AD
1c08	BC
1dqj	BC
1tht	AB
1mzg	AB
1fsk	AC
1pkq	BE
1nca	NH
1gjy	BD
1bhg	AB
Cluster Number:	179
1hnn	AB
1mcz	AC
1gze	AD
1ql3	AC
1nsw	AB
1jfm	BC
1oqd	AK
Cluster Number:	221
1nfi	AB
1kx5	AE
1ram	AB
1bft	AB
1le9	AB
1aoi	AE
1a3q	AB
1gd8	AB
1buh	AB
1spp	AB
Cluster Number:	350
1dan	LH
1aut	CL
1pfx	CL
1cvw	LH
1qfk	LH
1ioe	AL
1xka	LC
Cluster Number:	356
1fm6	AD
1pq6	AB
1dkf	AB
1prg	AB
1g1u	AB
1r20	AD
Cluster Number:	673
1i9r	AB
1jh5	AB
1iqa	AB
1d0g	AB
1a8m	AB
Cluster Number:	694
1d6r	AI
4sgb	EI
1ppf	EI
1oyv	BI
1r0r	EI
1cse	EI
2sic	EI
1c9t	AG
1sgd	EI
1oph	AB
1an1	EI
1f2s	EI
1brb	EI
1avw	AB
1acb	EI
1gl0	EI
1azz	AC
1ezs	AD
1p0s	EH
1fle	EI
1eai	AC
Cluster Number:	951
1iep	AB
1dtj	AD
1opl	AB
1i5f	AB
1iyb	AB
1h4g	AB
1jl3	BC
Cluster Number:	1227
1ic5	LY
1nby	AC
1ayp	AF
1ncn	AB
1f2x	KL
1oa3	BC
1aap	AB
3hoh	AC
1b06	CF
1ilu	CD
1lk3	AH
1gto	AB
1opa	AB
1nyt	CD
1a2y	BC
1fdl	HY
1dvf	BD
1dbr	AD
1ibq	AB
1ezx	AC
1znc	AB
1qo3	AC
1kuz	AB
Cluster Number:	1250
1e92	AC
1cyd	AD
1jw7	AC
1mxf	AC
1nhd	CD
1cwu	AB
1px0	AD
1bvr	CF
Cluster Number:	1588
1apy	BD
1rhg	BC
1ov8	AB
1mol	AB
1ies	BF
Cluster Number:	1596
1ce9	AB
1dip	AB
1tmz	AB
1zii	AB
1cz7	AB
1llm	CD
1kd8	AB
1dh3	AC
1jun	AB
1a02	FJ
1fos	GH
1h8a	AB
1ci6	AB
1kql	AB
1gk6	AB
1gd2	EF
1ihq	AB
1deb	AB
1fbm	AB
1hwt	CD
1zme	CD
Cluster Number:	1649
1fnt	BC
1g0u	BC
1g65	DE
1g65	FG
1fnt	FG
Cluster Number:	1855
1kbn	AB
1c72	AB
1pd2	12
1axd	AB
1b48	AB
Cluster Number:	1866
1k6j	AB
1kps	BD
1eqz	BD
1c5f	CE
1fbi	HX
1bhc	AG
1a9x	AE
1op9	AB
Cluster Number:	1867
1lbh	AC
1h8b	AB
1nu1	JK
2mlt	AB
1um3	OT
1um3	PQ
1emu	AB
Cluster Number:	1883
1fm6	DE
2prg	AC
1nrl	AC
1p8d	AC
1m2z	AB
1qd6	AC
1j2x	AB
1gng	AX
1g1e	AB
Cluster Number:	1885
1fo0	BH
1vfb	AC
1i8h	AB
1igo	AB
1mwa	BH
Cluster Number:	1918
1ac6	AB
1d9k	AB
1kb5	AB
1ao7	DE
1wtl	AB
1mvu	AB
1om3	HL
Cluster Number:	1962
1kx5	EF
1taf	AB
1jfi	AB
1n1j	AB
1b67	AB
1aoi	AB
Cluster Number:	1967
1a0n	AB
1oeb	AD
1ju5	AC
1jeg	AB
2bi6	LH
1ov3	AD
Cluster Number:	1980
1fa0	AB
1k4k	BD
1bzw	AB
1ktk	AC
1oof	AB
Cluster Number:	1982
1fd3	CD
1bc2	AB
1stm	AE
1ub3	AB
1avq	AB
1bon	AB
1hit	AB
1ekt	AB
1e3k	AB
1dq8	AC
1oft	AB
1dm9	AB
1orj	AC
1ixr	BC
1ixs	AB
1fqw	AB
1k2x	AD
Cluster Number:	1985
1kca	AD
1n4p	AK
1ggg	AB
1dks	AB
1kc4	AB
Cluster Number:	2155
1d2h	AB
1q5v	BD
1ous	AD
1jy4	AB
1rb3	AB
1k09	AB
1nhu	AB
1jpp	BD
Cluster Number:	2159
1kil	AB
1l4a	CD
1n7s	CD
1l4a	AB
1jth	AB
1n7s	AB
1sfc	AB
1kil	AD
1n7s	AD
1sfc	AD
Cluster Number:	2163
1swi	BC
1gcm	AB
1ce0	AB
1c94	AB
1jcd	AB
2pah	AB
Cluster Number:	2168
1xxc	BF
1fdq	AB
5cro	AB
1a78	AB
1dtj	AB
1a8t	AB
1mfh	AB
1ith	AB
1bre	AD
1mhh	AE
1igc	AH
1cf1	AB
2phi	AB
1n4p	BJ
1ji7	BC
1ji7	AB
1e69	AB
1dee	DG
1m8k	AB
1jkx	AB
1kpt	AB
1i22	AD
1rho	AC
1ae9	AB
1udr	AD
1nw2	AD
1ep7	AB
1tsr	AB
1d4f	AD
1ezv	EX
1geq	AB
1rpm	AB
1b77	AB
1hzd	AD
1cfz	AE
1a19	AB
1fb0	AB
1cku	AB
1pui	AB
1cje	AB
1mkz	AB
1jd4	AB
1b4a	BC
1b4b	AB
1bu1	AB
1ddj	AB
1g28	AC
1dzb	AB
1czv	AB
1kcg	BC
1dee	DG
1hyr	AC
1qfo	BC
1h6g	AB
1jbb	AB
1h4o	BC
1k9j	AB
1g16	CD
Cluster Number:	2171
1jb0	AC
1ngk	CK
1dqi	AD
1i84	TV
1l8l	AB
1efn	AB
1dch	BD
1lvf	AB
1hyh	AD
1a9x	AG
Cluster Number:	2172
1ca0	CD
1hja	CI
1n8o	CE
2kai	BI
1hia	BI
1sgf	BG
1fi8	AC
Cluster Number:	2173
1jx7	AB
1dg1	GH
1g1o	AC
1aoh	AB
1mg2	NO
Cluster Number:	2174
1ezg	AB
1a7v	AB
1l0s	AB
1m0z	AB
1m8n	AB
1a4b	AB
1uex	BC
1aar	AB
1b25	AB
1jx7	AF
Cluster Number:	2199
1axc	AC
1qf8	AB
1tyf	AH
1eah	24
1gyo	AB
1n7f	AB
Cluster Number:	2266
1d3b	CD
1kq1	AB
1i81	AB
1b34	AB
1m5q	AB
Cluster Number:	2267
1uix	AB
1ic2	CD
1gk4	CD
1n6m	AB
1nkn	AB
Cluster Number:	2269
1g3m	AB
1n1l	AB
1n6j	AG
2vub	AD
1lxn	AD
1npo	AC
1fyz	AB
1cmx	AC
1r4o	AB
1fqo	AB
1l0o	BC
1cf2	PQ
1csk	AB
43c9	DF
1g4a	BD
1idh	AB
1d1z	AB
1e6j	HP
Cluster Number:	2407
1nw2	BH
1a2k	BE
1pf9	AO
1do5	AC
1g9m	GH
1lk0	AB
1ft8	BD
Cluster Number:	2429
1h0x	AB
1q3e	AB
1ii7	AB
1vdr	AB
1iz5	AB
1iss	AB
1jaf	AB
Cluster Number:	2447
3msp	AB
1qsw	BC
1i2s	AB
1muq	AB
1oia	AB
Cluster Number:	2530
1fse	CF
1dfn	AB
1i0c	AB
1xxc	DE
1o84	AB