Functional Sites Structural Search Engine [About SiteEngine][ Server Help][ Download Software]
Recognizes regions on the surface of one protein that resemble a specific binding site of another.

Type the PDB code of the molecule that you would like to be searched (can be unbound).
Complete molecule (1): (e.g. 1lhu)
Type the PDB code of the molecule that has a binding sites of interest (complexed with small molecule).
Extract the binding site from the molecule (2): (e.g. 1a27)
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* The link to the output page will be sent by email *

Please cite the following references:
1.Shulman-Peleg A, Nussinov R, Wolfson H.J., Recognition of functional sites in protein structures. J Mol Biol. 2004 Jun 4;339(3):607-33 [PDF] [ScienceDirect Link]
2.Shulman-Peleg A, Nussinov R, Wolfson H.J. SiteEngines: Recognition and Comparison of Binding Sites and Protein-Protein Interfaces, Nucleic Acids Research, 2005, Vol. 33 (Web Server Issue):W337-W341 [Link].