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There are several motivations for such methods. First, analysis and classification of protein-protein interfaces may help to recognize certain binding organizations shared by different protein families. The common features may be important for the formation and stability of the protein-protein complex. Their recognition may assist in discovery of new drug leads that target these centers of interaction. Moreover, it can help in lead optimization and prediction of side effects caused by the inhibition of the other complex. In addition, given a structure of a novel complex with an unknown function, the method can be applied to recognize complexes with similar binding organizations which may provide hits for its biological function.